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Tripamide

From Wikipedia, the free encyclopedia
Tripamide
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 3-(aminosulfonyl)-4-chloro-N-[(3aR,4S,7R,7aS)-octahydro-2H-4,7-methanoisoindol-2-yl]benzamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H20ClN3O3S
Molar mass369.86 g·mol−1
3D model (JSmol)
  • C1C[C@@H]2C[C@H]1[C@@H]3[C@H]2CN(C3)NC(=O)C4=CC(=C(C=C4)Cl)S(=O)(=O)N
  • InChI=1S/C16H20ClN3O3S/c17-14-4-3-11(6-15(14)24(18,22)23)16(21)19-20-7-12-9-1-2-10(5-9)13(12)8-20/h3-4,6,9-10,12-13H,1-2,5,7-8H2,(H,19,21)(H2,18,22,23)/t9-,10+,12-,13+
  • Key:UHLOVGKIEARANS-NIFPGPBJSA-N
  (verify)

Tripamide (INN) is a diuretic.

Diels-Alder reaction between maleimide and cyclopentadiene gives a compound that is called noreximide [6319-06-8].[1] This compound is of utility not merely in the production of tripamide, but also in the synthesis of taglutimide, lurasidone, tandospirone, perospirone (close) and lastly a pesticide that is called MGK 264.

Tecovirimat has a structure that is related to tripamide but with some important differences.

References

[edit]
  1. Culberson, C. F., Wilder, P. (August 1960). "The Synthesis of 2-Aza-1,2-dihydrodicyclopentadienes 1,2". The Journal of Organic Chemistry. 25 (8): 1358–1362. doi:10.1021/jo01078a018.