Module talk:Infobox gene/testcases 2

• Module talk:Infobox gene/testcases

AIF1

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AIF1 Identifiers Aliases AIF1, AIF-1, IBA1, IRT-1, IRT1, allograft inflammatory factor 1, Iba-1 External IDs OMIM: 601833; MGI: 1343098; GeneCards: AIF1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D58, 2G2B Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,615,217 bp End 31,617,021 bp Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.59 cM Start 35,389,967 bp End 35,395,044 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte bone marrow cell testicle right lung gallbladder C1 segment rectum spleen right coronary artery Top expressed in seminiferous tubule mesenteric lymph nodes spermatid spleen stroma of bone marrow thymus spermatocyte subcutaneous adipose tissue optic nerve aortic valve More reference expression data BioGPS More reference expression data Gene ontology Molecular function calcium ion binding metal ion binding actin filament binding actin binding molecular function Cellular component cytoplasm cytosol perikaryon cell projection membrane ruffle plasma membrane ruffle membrane actin filament perinuclear region of cytoplasm phagocytic cup cytoskeleton nucleus lamellipodium Biological process cellular response to extracellular stimulus positive regulation of smooth muscle cell chemotaxis response to cytokine positive regulation of protein phosphorylation negative regulation of smooth muscle cell proliferation positive regulation of cell migration positive regulation of muscle hyperplasia positive regulation of nitric oxide biosynthetic process positive regulation of monocyte chemotaxis negative regulation of apoptotic process response to glucocorticoid response to electrical stimulus negative regulation of gene expression cellular response to hydroperoxide actin filament bundle assembly microglial cell activation positive regulation of G1/S transition of mitotic cell cycle actin filament polymerization negative regulation of smooth muscle cell chemotaxis cellular response to hormone stimulus phagocytosis, engulfment response to axon injury positive regulation of T cell proliferation cellular response to interferon-gamma cellular response to morphine Rac protein signal transduction inflammatory response ruffle assembly positive regulation of T cell migration positive regulation of smooth muscle cell proliferation cerebellum development positive regulation of cell population proliferation regulation of gene expression parallel actin filament bundle assembly cellular response to oxidative stress positive regulation of chemotaxis actin crosslink formation positive regulation of mononuclear cell migration positive regulation of fibroblast growth factor production Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 199 11629 Ensembl ENSG00000206428 ENSG00000235985 ENSG00000235588 ENSG00000234836 ENSG00000237727 ENSG00000204472 ENSMUSG00000024397 UniProt P55008 Q4V347 O70200 RefSeq (mRNA) NM_001623 NM_004847 NM_032955 NM_001318970 NM_019467 NM_001361501 NM_001361502 RefSeq (protein) NP_001305899 NP_001614 NP_116573 NP_001614.3 NP_062340 NP_001348430 NP_001348431 Location (UCSC) Chr 6: 31.62 – 31.62 Mb Chr 17: 35.39 – 35.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse

AIF1 Identifiers Aliases AIF1, AIF-1, IBA1, IRT-1, IRT1, allograft inflammatory factor 1, Iba-1 External IDs OMIM: 601833; MGI: 1343098; GeneCards: AIF1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D58, 2G2B Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 31,615,217 bp End 31,617,021 bp Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.59 cM Start 35,389,967 bp End 35,395,044 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte bone marrow cell testicle right lung gallbladder C1 segment rectum spleen right coronary artery Top expressed in seminiferous tubule mesenteric lymph nodes spermatid spleen stroma of bone marrow thymus spermatocyte subcutaneous adipose tissue optic nerve aortic valve More reference expression data BioGPS More reference expression data Gene ontology Molecular function calcium ion binding metal ion binding actin filament binding actin binding molecular function Cellular component cytoplasm cytosol perikaryon cell projection membrane ruffle plasma membrane ruffle membrane actin filament perinuclear region of cytoplasm phagocytic cup cytoskeleton nucleus lamellipodium Biological process cellular response to extracellular stimulus positive regulation of smooth muscle cell chemotaxis response to cytokine positive regulation of protein phosphorylation negative regulation of smooth muscle cell proliferation positive regulation of cell migration positive regulation of muscle hyperplasia positive regulation of nitric oxide biosynthetic process positive regulation of monocyte chemotaxis negative regulation of apoptotic process response to glucocorticoid response to electrical stimulus negative regulation of gene expression cellular response to hydroperoxide actin filament bundle assembly microglial cell activation positive regulation of G1/S transition of mitotic cell cycle actin filament polymerization negative regulation of smooth muscle cell chemotaxis cellular response to hormone stimulus phagocytosis, engulfment response to axon injury positive regulation of T cell proliferation cellular response to interferon-gamma cellular response to morphine Rac protein signal transduction inflammatory response ruffle assembly positive regulation of T cell migration positive regulation of smooth muscle cell proliferation cerebellum development positive regulation of cell population proliferation regulation of gene expression parallel actin filament bundle assembly cellular response to oxidative stress positive regulation of chemotaxis actin crosslink formation positive regulation of mononuclear cell migration positive regulation of fibroblast growth factor production Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 199 11629 Ensembl ENSG00000206428 ENSG00000235985 ENSG00000235588 ENSG00000234836 ENSG00000237727 ENSG00000204472 ENSMUSG00000024397 UniProt P55008 Q4V347 O70200 RefSeq (mRNA) NM_001623 NM_004847 NM_032955 NM_001318970 NM_019467 NM_001361501 NM_001361502 RefSeq (protein) NP_001305899 NP_001614 NP_116573 NP_001614.3 NP_062340 NP_001348430 NP_001348431 Location (UCSC) Chr 6: 31.62 – 31.62 Mb Chr 17: 35.39 – 35.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse

AKR1C3

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AKR1C3 Identifiers Aliases AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS, aldo-keto reductase family 1, member C3, aldo-keto reductase family 1 member C3 External IDs OMIM: 603966; MGI: 2145420; GeneCards: AKR1C3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB, 3R43, 3R58, 3R6I, 3R7M, 3R8G, 3R8H, 3R94, 3UFY, 3UG8, 3UGR, 3UWE, 4DBS, 4DBU, 4DBW, 4DZ5, 4FA3, 4FAL, 4FAM, 4H7C, 4HMN, 4WDT, 4WDU, 4WDW, 4WDX, 4WRH, 4XVD, 4XVE, 4ZFC, 4YVX, 4YVV Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 1.1.1.53 ↗ ↗ ↗ ↗ 1.1.1.62 ↗ ↗ ↗ ↗ 1.1.1.64 ↗ ↗ ↗ ↗ 1.1.1.188 ↗ ↗ ↗ ↗ 1.1.1.210 ↗ ↗ ↗ ↗ 1.1.1.239 ↗ ↗ ↗ ↗ 1.1.1.357 ↗ ↗ ↗ ↗ 1.3.1.20 ↗ ↗ ↗ ↗ Gene location (Human) Chr. Chromosome 10 (human) Band 10p15.1 Start 5,035,354 bp End 5,107,686 bp Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A1 Start 4,182,614 bp End 4,200,653 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa pancreatic ductal cell gallbladder duodenum mucosa of ileum right lobe of liver kidney tubule islet of Langerhans mucosa of transverse colon skin of hip Top expressed in skin of external ear lacrimal gland right kidney lip conjunctival fornix parotid gland proximal tubule gastrula human kidney decidua More reference expression data BioGPS More reference expression data Gene ontology Molecular function delta4-3-oxosteroid 5beta-reductase activity prostaglandin-F synthase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity retinal dehydrogenase activity geranylgeranyl reductase activity indanol dehydrogenase activity aldo-keto reductase (NADP) activity dihydrotestosterone 17-beta-dehydrogenase activity phenanthrene 9,10-monooxygenase activity ketoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor testosterone dehydrogenase (NAD+) activity NAD-retinol dehydrogenase activity testosterone 17-beta-dehydrogenase (NADP+) activity oxidoreductase activity androsterone dehydrogenase activity 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ketosteroid monooxygenase activity NADP-retinol dehydrogenase activity prostaglandin D2 11-ketoreductase activity prostaglandin H2 endoperoxidase reductase activity alcohol dehydrogenase (NADP+) activity steroid dehydrogenase activity Cellular component cytoplasm cytosol intracellular anatomical structure extracellular exosome nucleus Biological process cellular response to calcium ion negative regulation of retinoic acid biosynthetic process prostaglandin metabolic process G protein-coupled receptor signaling pathway cellular response to jasmonic acid stimulus steroid metabolic process positive regulation of protein kinase B signaling male gonad development positive regulation of cell death daunorubicin metabolic process doxorubicin metabolic process response to nutrient regulation of retinoic acid receptor signaling pathway progesterone metabolic process cellular response to starvation regulation of testosterone biosynthetic process cellular response to cadmium ion cellular response to corticosteroid stimulus cyclooxygenase pathway keratinocyte differentiation retinal metabolic process retinoid metabolic process cellular response to reactive oxygen species farnesol catabolic process positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process cellular response to prostaglandin D stimulus positive regulation of cell population proliferation renal absorption testosterone biosynthetic process cellular response to prostaglandin stimulus retinol metabolic process macromolecule metabolic process Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8644 105349 Ensembl ENSG00000196139 ENSMUSG00000021214 UniProt P42330 Q8K023 RefSeq (mRNA) NM_003739 NM_001253908 NM_001253909 NM_016253 NM_134066 NM_001346535 RefSeq (protein) NP_001240837 NP_001240838 NP_003730 NP_001333464 NP_598827 Location (UCSC) Chr 10: 5.04 – 5.11 Mb Chr 13: 4.18 – 4.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse

AKR1C3 Identifiers Aliases AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS, aldo-keto reductase family 1, member C3, aldo-keto reductase family 1 member C3 External IDs OMIM: 603966; MGI: 2145420; GeneCards: AKR1C3 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB, 3R43, 3R58, 3R6I, 3R7M, 3R8G, 3R8H, 3R94, 3UFY, 3UG8, 3UGR, 3UWE, 4DBS, 4DBU, 4DBW, 4DZ5, 4FA3, 4FAL, 4FAM, 4H7C, 4HMN, 4WDT, 4WDU, 4WDW, 4WDX, 4WRH, 4XVD, 4XVE, 4ZFC, 4YVX, 4YVV Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 1.1.1.53 ↗ ↗ ↗ ↗ 1.1.1.62 ↗ ↗ ↗ ↗ 1.1.1.64 ↗ ↗ ↗ ↗ 1.1.1.188 ↗ ↗ ↗ ↗ 1.1.1.210 ↗ ↗ ↗ ↗ 1.1.1.239 ↗ ↗ ↗ ↗ 1.1.1.357 ↗ ↗ ↗ ↗ 1.3.1.20 ↗ ↗ ↗ ↗ Gene location (Human) Chr. Chromosome 10 (human) Band 10p15.1 Start 5,035,354 bp End 5,107,686 bp Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A1 Start 4,182,614 bp End 4,200,653 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa pancreatic ductal cell gallbladder duodenum mucosa of ileum right lobe of liver kidney tubule islet of Langerhans mucosa of transverse colon skin of hip Top expressed in skin of external ear lacrimal gland right kidney lip conjunctival fornix parotid gland proximal tubule gastrula human kidney decidua More reference expression data BioGPS More reference expression data Gene ontology Molecular function delta4-3-oxosteroid 5beta-reductase activity prostaglandin-F synthase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity alditol:NADP+ 1-oxidoreductase activity retinal dehydrogenase activity geranylgeranyl reductase activity indanol dehydrogenase activity aldo-keto reductase (NADP) activity dihydrotestosterone 17-beta-dehydrogenase activity phenanthrene 9,10-monooxygenase activity ketoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor testosterone dehydrogenase (NAD+) activity NAD-retinol dehydrogenase activity testosterone 17-beta-dehydrogenase (NADP+) activity oxidoreductase activity androsterone dehydrogenase activity 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ketosteroid monooxygenase activity NADP-retinol dehydrogenase activity prostaglandin D2 11-ketoreductase activity prostaglandin H2 endoperoxidase reductase activity alcohol dehydrogenase (NADP+) activity steroid dehydrogenase activity Cellular component cytoplasm cytosol intracellular anatomical structure extracellular exosome nucleus Biological process cellular response to calcium ion negative regulation of retinoic acid biosynthetic process prostaglandin metabolic process G protein-coupled receptor signaling pathway cellular response to jasmonic acid stimulus steroid metabolic process positive regulation of protein kinase B signaling male gonad development positive regulation of cell death daunorubicin metabolic process doxorubicin metabolic process response to nutrient regulation of retinoic acid receptor signaling pathway progesterone metabolic process cellular response to starvation regulation of testosterone biosynthetic process cellular response to cadmium ion cellular response to corticosteroid stimulus cyclooxygenase pathway keratinocyte differentiation retinal metabolic process retinoid metabolic process cellular response to reactive oxygen species farnesol catabolic process positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process cellular response to prostaglandin D stimulus positive regulation of cell population proliferation renal absorption testosterone biosynthetic process cellular response to prostaglandin stimulus retinol metabolic process macromolecule metabolic process Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8644 105349 Ensembl ENSG00000196139 ENSMUSG00000021214 UniProt P42330 Q8K023 RefSeq (mRNA) NM_003739 NM_001253908 NM_001253909 NM_016253 NM_134066 NM_001346535 RefSeq (protein) NP_001240837 NP_001240838 NP_003730 NP_001333464 NP_598827 Location (UCSC) Chr 10: 5.04 – 5.11 Mb Chr 13: 4.18 – 4.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse

Monoamine oxidase B

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MAOB Identifiers Aliases MAOB, Monoamine oxidase B External IDs OMIM: 309860; MGI: 96916; GeneCards: MAOB Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GOS, 1OJ9, 1OJA, 1OJC, 1OJD, 1S2Q, 1S2Y, 1S3B, 1S3E, 2BK3, 2BK4, 2BK5, 2BYB, 2C64, 2C65, 2C66, 2C67, 2C70, 2C72, 2C73, 2C75, 2C76, 2V5Z, 2V60, 2V61, 2VRL, 2VRM, 2VZ2, 2XCG, 2XFN, 2XFO, 2XFP, 2XFQ, 2XFU, 3PO7, 3ZYX, 4A79, 4A7A, 4CRT Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 1.4.3.4 ↗ ↗ ↗ ↗ 1.4.3.21 ↗ ↗ ↗ ↗ Gene location (Human) Chr. X chromosome (human) Band Xp11.3 Start 43,766,610 bp End 43,882,450 bp Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.2|X 11.88 cM Start 16,575,521 bp End 16,683,605 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein external globus pallidus decidua tail of epididymis middle frontal gyrus hypothalamus left ovary superior vestibular nucleus liver right lobe of liver Top expressed in epithelium of small intestine left lobe of liver Epithelium of choroid plexus upper respiratory tract nasal epithelium olfactory epithelium medial dorsal nucleus islet of Langerhans interventricular septum myocardium of ventricle More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein homodimerization activity flavin adenine dinucleotide binding electron transfer activity oxidoreductase activity primary amine oxidase activity Cellular component integral component of membrane membrane mitochondrial outer membrane mitochondrion mitochondrial inner membrane mitochondrial envelope extracellular exosome Biological process response to selenium ion substantia nigra development response to corticosterone response to steroid hormone negative regulation of serotonin secretion response to lipopolysaccharide response to aluminum ion dopamine catabolic process hydrogen peroxide biosynthetic process response to ethanol response to toxic substance positive regulation of dopamine metabolic process neurotransmitter catabolic process electron transport chain Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4129 109731 Ensembl ENSG00000069535 ENSMUSG00000040147 UniProt P27338 Q8BW75 RefSeq (mRNA) NM_000898 NM_172778 RefSeq (protein) NP_000889 NP_766366 Location (UCSC) Chr X: 43.77 – 43.88 Mb Chr X: 16.58 – 16.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse

MAOB Identifiers Aliases MAOB, Monoamine oxidase B External IDs OMIM: 309860; MGI: 96916; GeneCards: MAOB Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GOS, 1OJ9, 1OJA, 1OJC, 1OJD, 1S2Q, 1S2Y, 1S3B, 1S3E, 2BK3, 2BK4, 2BK5, 2BYB, 2C64, 2C65, 2C66, 2C67, 2C70, 2C72, 2C73, 2C75, 2C76, 2V5Z, 2V60, 2V61, 2VRL, 2VRM, 2VZ2, 2XCG, 2XFN, 2XFO, 2XFP, 2XFQ, 2XFU, 3PO7, 3ZYX, 4A79, 4A7A, 4CRT Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 1.4.3.4 ↗ ↗ ↗ ↗ 1.4.3.21 ↗ ↗ ↗ ↗ Gene location (Human) Chr. X chromosome (human) Band Xp11.3 Start 43,766,610 bp End 43,882,450 bp Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.2|X 11.88 cM Start 16,575,521 bp End 16,683,605 bp RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein external globus pallidus decidua tail of epididymis middle frontal gyrus hypothalamus left ovary superior vestibular nucleus liver right lobe of liver Top expressed in epithelium of small intestine left lobe of liver Epithelium of choroid plexus upper respiratory tract nasal epithelium olfactory epithelium medial dorsal nucleus islet of Langerhans interventricular septum myocardium of ventricle More reference expression data BioGPS More reference expression data Gene ontology Molecular function protein homodimerization activity flavin adenine dinucleotide binding electron transfer activity oxidoreductase activity primary amine oxidase activity Cellular component integral component of membrane membrane mitochondrial outer membrane mitochondrion mitochondrial inner membrane mitochondrial envelope extracellular exosome Biological process response to selenium ion substantia nigra development response to corticosterone response to steroid hormone negative regulation of serotonin secretion response to lipopolysaccharide response to aluminum ion dopamine catabolic process hydrogen peroxide biosynthetic process response to ethanol response to toxic substance positive regulation of dopamine metabolic process neurotransmitter catabolic process electron transport chain Sources:Amigo / QuickGO Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4129 109731 Ensembl ENSG00000069535 ENSMUSG00000040147 UniProt P27338 Q8BW75 RefSeq (mRNA) NM_000898 NM_172778 RefSeq (protein) NP_000889 NP_766366 Location (UCSC) Chr X: 43.77 – 43.88 Mb Chr X: 16.58 – 16.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse

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