DMG-PEG 2000

DMG-PEG 2000
Names
	IUPAC name 1,2-Dimyristoyl-sn-glycero-3-methoxypolyethylene glycol
	Other names PEG-DMG
Identifiers
CAS Number	1397695-86-1;
3D model (JSmol)	Interactive image;
ChemSpider	98644331;
PubChem CID	122629501;
	InChI InChI=1S/C122H242O50/c1-4-6-8-10-12-14-16-18-20-22-24-26-121(123)171-119-120(172-122(124)27-25-23-21-19-17-15-13-11-9-7-5-2)118-170-117-116-169-115-114-168-113-112-167-111-110-166-109-108-165-107-106-164-105-104-163-103-102-162-101-100-161-99-98-160-97-96-159-95-94-158-93-92-157-91-90-156-89-88-155-87-86-154-85-84-153-83-82-152-81-80-151-79-78-150-77-76-149-75-74-148-73-72-147-71-70-146-69-68-145-67-66-144-65-64-143-63-62-142-61-60-141-59-58-140-57-56-139-55-54-138-53-52-137-51-50-136-49-48-135-47-46-134-45-44-133-43-42-132-41-40-131-39-38-130-37-36-129-35-34-128-33-32-127-31-30-126-29-28-125-3/h120H,4-119H2,1-3H3 Key: NLDCRRFPGOSAHV-UHFFFAOYSA-N;
	SMILES O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC;
Properties
Chemical formula	C122H242O50
Molar mass	570.89
Appearance	powder
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H315, H319
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

DMG-PEG 2000 is a synthetic lipid formed by the PEGylation of myristoyl diglyceride. It is used to manufacture lipid nanoparticles that are used in mRNA vaccines,^[3] and in particular forms part of the drug delivery system for the Moderna COVID-19 vaccine.^[4]

Main applications

DMG-PEG 2000 has similar chemical properties to the phospholipids that make up the cell membrane. This enables lipid nanoparticles composed of it to easily merge with the cell membrane, delivering its contents. ^[1]

References

1 2 3 "DMG-PEG 2000 powder".
1 2 3 "DMG-PEG(2000)".
↑ Shirane D, Tanaka H, Nakai Y, Yoshioka H, Akita H (2018). "Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA". Biological & Pharmaceutical Bulletin. 41 (8): 1291–1294. doi:10.1248/bpb.b18-00208. PMID 30068880.
↑ "Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older" (PDF). Centers for Disease Control and Prevention (CDC).

[sa-1] 1 2 3 "DMG-PEG 2000 powder".

[chembook-2] 1 2 3 "DMG-PEG(2000)".

[pmid30068880-3] Shirane D, Tanaka H, Nakai Y, Yoshioka H, Akita H (2018). "Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA". Biological & Pharmaceutical Bulletin. 41 (8): 1291–1294. doi:10.1248/bpb.b18-00208. PMID 30068880.

[CDC_standing_order-4] "Moderna COVID-19 Vaccine Standing Orders for Administering Vaccine to Persons 18 Years of Age and Older" (PDF). Centers for Disease Control and Prevention (CDC).

[1]

[2]

[3]

[4]

Main applications

See also

References